What is Actos?
In 1999 Takeda Pharmaceuticals received FDA approval for its Type 2 Diabetes medication Actos. The drug quickly became one of the company’s largest streams of revenue, making up more than 20 percent of the manufacturer’s total income. Actos, a type of thiazolidinedione, works in different ways to help patients with Type 2 diabetes. The medication decreases resistance to insulin; makes cells more receptive to insulin; and better allows the body to use and dispose of excess blood sugar. But Actos also bears a number of harmful side effects.
Side Effects and Risks
Researchers are now associating Actos with a number of serious side effects. The drug has been linked to conditions such as congestive heart failure, liver failure, bone fractures, heart attack and kidney failure. In addition, the link between Actos and the development of bladder cancer is a recent major concern that has been expressed by the FDA.
In 2011, the FDA released a statement announcing the propensity of Actos to cause bladder cancer, especially when used for a time greater than one year. This information was the result of a five-year study of pioglitazone, which is the active ingredient in Actos. The research found that users of the medication, especially Actos, had a higher risk for developing cancerous tumors in the bladder. The FDA safety announcement advised that those who have, or have had, bladder cancer should not use drugs containing pioglitazone. In addition users are advised to be vigilant in detecting signs of bladder cancer such as:
- Bloody urine
- Back and abdominal pain
- Urgency in need to urinate
- Pain while urinating
Negligence on Behalf of The Manufacturer
Lawsuits have been filed alleging that Takeda Pharmaceuticals withheld information about the link between bladder cancer and the use of Actos. Many claim that the manufacturer acted negligently in marketing the drug, subsequently leading to users developing bladder cancer, among other dangerous conditions. In April 2015, Takeda Pharmaceuticals settled the largest number of claims in United States history, paying over $2 billion dollars for more than 9,000 claims.
Legal Aid for Users
Consumers who have suffered from bladder cancer while taking Actos should consult legal representation. Attorneys will be able to evaluate user claims and assess whether one may be eligible for legal action. If you believe that you or a loved one have been affected, contact The Law Offices of Peter G. Angelos, P.C. for a no-charge consultation.